Jason H. Pomerantz, M.D.
- Professor of Surgery
- Division of Plastic and Reconstructive Surgery
- Co-chair, Department of Surgery Research Committee
- Surgical Director, Craniofacial Center
- Director, Pomerantz Lab
Contact Information
UCSF Medical Center
Division of Plastic & Reconstructive Surgery
(415) 353-4389 phone
(415) 353-4330 fax
Division of Plastic & Reconstructive Surgery
(415) 353-4389 phone
(415) 353-4330 fax
Education
- 1990-1994 University of Pennsylvania, B.A. Biology
- 1994-2000 Albert Einstein College of Medicine, M.D.
Residencies
- 2000-2001 University of California-San Francisco, Intern General Surgery
- 2001-2003 University of California-San Francisco, Residency General Surgery
- 2006-2008 University of California-San Francisco, Residency Plastic Surgery
Fellowships
- 1996-1998 Howard Hughes Medical Institute, Researh Training Fellowship
- 2008-2009 University of Washington, Seattle, Craniofacial Surgery Fellowship
Biography
Jason Pomerantz, M.D. is an associate professor in the Division of Plastic and Reconstructive Surgery surgical director of the UCSF Craniofacial Center, and Director of the Pomerantz Lab. Dr. Pomerantz treats congenital and acquired deformities of the head and face, in both adults and children, including cleft lip and palate, craniosynostosis, and traumatic facial injuries. Dr. Pomerantz's NIH-funded research program focuses on the investigation of basic and translational aspects of tissue regeneration relevant to regeneration medicine.
Dr. Pomerantz earned his medical degree at the Albert Einstein College of Medicine. He completed a residency at UCSF, a postdoctoral research fellowship in regeneration biology at Stanford University, and a fellowship in craniofacial surgery at the University of Washington.
With foundations in muscle, stem cell and cancer biology, his laboratory aims to develop novel approaches that will impact the treatment of structural disorders and deformities. Dr. Pomerantz is a researcher at the UCSF Program in Craniofacial Biology (PCB), and has affiliations with the UCSF Biomedical Sciences (BMS) Graduate Program, and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF.
Ultimately, Dr. Pomerantz hopes to identify the genes responsible for regeneration, genes that have evolved differently between species. This has implications for the reconstruction of damaged or missing tissue resulting from congenital abnormalities and those acquired as a result of trauma.
Awards & Honors
Award
Confired By
Date
Research Overview
The research program of our lab is closely intertwined with regenerative medicine. With foundations in muscle and cancer biology, we are investigating regenerative mechanisms including stem cell development and de-differentiation. By employing model organisms such as zebrafish and mouse and extending discoveries to human cells and tissues, we hope to gain fundamental insight that can be translated into clinical advances, most notably solving the structural and reconstructive problems of the limbs, face, and head, whether congenital or acquired.
Research & Funding
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- UCSF Craniofacial Clinical Translational Science InitiativeSponsor: University of California San Francisco School of Dentistry, Caroline Damsky fundSponsor ID:Funding Period:Jul 2015-Jun 2025
- Bioinspired hydrogels for craniofacial muscle regenerationFunding Period:Jan 2019-Apr 2023
- Regeneration and Differentiation Potential of Heterogeneous Human Satellite CellsSponsor: NIHSponsor ID: R01AR072638Funding Period:Sep 2017-Aug 2022Principal Investigator
- Sustained local delivery of pharmacological agents via nanoengineered films to improve healing of craniofacial fractures: comparative pre-clinical evaluation of BMP and deferoxamine in prevalent high-risk injuriesFunding Period:Jan 2019-Dec 2019Co-PI
- Skeletal Muscle Regeneration by Human Satellite Cells Following DenervationSponsor: Plastic Surgery FoundationSponsor ID:Funding Period:Jul 2016-Jun 2019
- Characterization of Human Skeletal Muscle Stem Cells for Clinical ApplicationSponsor: CIRMSponsor ID: RN3-06504Funding Period:Mar 2013-Sep 2018
- Evaluation of satellite cell function and transplantation in rotator cuff injurySponsor: CCMBMSponsor ID: 1P30AR066262-01Funding Period:Dec 2016-Jun 2018
- Basic Biology III -Phenotypic Analysis of Human ES Cell-Derived Muscle Stem CellsSponsor: CIRMSponsor ID: RB3-05041Funding Period:Jul 2013-Jun 2015
- Mimicking Growth Control in Regenerative Organisms to Permit Mammalian RegenerationSponsor: Program for Breakthrough Biomedical ResearchSponsor ID:Funding Period:Apr 2010-Mar 2012
- Mechanisms Underlying Plasticity of Gene ExpressionSponsor: NIH/NIAMSSponsor ID: F32AR051678Funding Period:Sep 2004-Aug 2006Principal Investigator
Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 78
Data provided by UCSF Profiles, powered by CTSI
- Do A, Rorison E, Borucki A, Shibata GS, Pomerantz JH, Hoffman WY. Opioid-free Pain Management after Cleft Lip Repair. Plast Reconstr Surg Glob Open. 2023 Sep; 11(9):e5259. View in PubMed
- Danial E, Rios J, Badiee R, Rosenbluth G, Pomerantz JH. Analyzing Linguistic Disparities in Telehealth Care Outcomes at a Multidisciplinary Craniofacial Center. Cleft Palate Craniofac J. 2023 Aug 22; 10556656231187291. View in PubMed
- Perkins IU, Tan SY, McCalmont TH, Chou PM, Mully TW, Gerami P, Pomerantz JH, Reyes-Múgica M, Balkin DM, Kruse LL, Huang B, Reichek JL, Gangopadhyay N, Chiosea S, Green JR, Chamlin SL, Frieden IJ, Bastian BC, Yeh I. Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK). Pigment Cell Melanoma Res. 2023 Jul 20. View in PubMed
- Barruet E, Striedinger K, Marangoni P, Pomerantz JH. Loss of transcriptional heterogeneity in aged human muscle stem cells. PLoS One. 2023; 18(5):e0285018. View in PubMed
- Braun M, Pomerantz JH, Hoffman WY, Mathes EF. Long-pulsed neodymium-doped yttrium aluminum garnet for hair reduction in pediatric microtia repair. Pediatr Dermatol. 2023 Jul-Aug; 40(4):755-758. View in PubMed
- View All Publications
In the News
- UCSF Department of Surgery - - August 07, 2019The Department of Surgery is pleased to announce that Elizabeth C. Wick, M.D. and Jason H. Pomerantz, M.D. have been appointed Co-Chairs of the Department of Surgery Research Committee. Dr. Wick is a professor of surgery in the Section of Colorectal Surgery. She is an experienced laparoscopic surgeon, treating the entire spectrum of colorectal conditions including diverticular disease, inflammatory bowel disease, colon and rectal cancer, anal cancer, and perianal disease with a [...]
- Pomerantz Lab - - March 13, 2018Jason H. Pomerantz, M.D., associate professor of surgery and surgical director of the UCSF Craniofacial Center, has been awarded a 5-year $1.7M R01 grant from National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to study muscle stem cells, a subpopulation of muscle progenitors that are focal points of vulnerability in muscle dysfunction from disease, trauma or aging. Project Narrative "Muscle dysfunction from disease, trauma or aging, a major health care burden not [...]
- Pomerantz Lab - - June 09, 2017UCSF News reports on research in the UCSF Program in Craniofacial Biology using stem cells from patients with craniofacial deformities to better understand how these design flaws occur in fetal development. Among other research projects, the article reported on the work of Jason H. Pomerantz, M.D., Surgical Director of the UCSF Craniofacial Center, who is using stem cells and regenerative techniques to reconstruct tiny muscles in the face using a humanized organ in a mouse model. Together, [...]
- Pomerantz Lab - - December 22, 2016Alvin Wong, M.D., a plastic surgery research fellow in the Pomerantz Lab, was awarded a grant by the Plastic Surgery Foundation (PSF) to study "skeletal muscle regeneration by human satellite cells following denervation". The award, funded by a National Endowment for Plastic Surgery Grant, was one of eleven representing the "newest, clinically relevant research in plastic surgery". The grant to Dr. Wong is also notable in that most such awards go to established principal Investigators with [...]
- Pomerantz Lab - - November 01, 2016UCSF News reports on research by Xiaoti Xu, M.D. and a team in the Pomerantz Lab showing that human muscle stem cells could be transplanted into a new environment and have the capacity to regenerate lost muscle tissue. Dr. Xu is a UCSF Plastic Surgery Resident and former research fellow in the lab. The image shows cross-sectioned muscle fibers as black shapes outlined in green. The catch: these are human muscle fibers, grown from human stem cells. Xiaoti Xu, MD, a resident physician in UC [...]
- UCSF Pomerantz Lab - November 18, 2015UCSF News reports on new research of the Pomerantz Lab suggesting that future efforts to regrow or regenerate human tissue may require blocking the activity of a tumor-suppressor gene, ARF. The research involved adding the human ARF gene to a zebrafish, which prevented its normal ability to regenerate tissue, here the fish's tail fin that had been cut off. The research was led by Jason Pomerantz, MD, Associate Professor of Surgery in the Division of Plastic and Reconstructive Surgery, Surgical [...]
- UCSF Department of Surgery - - November 18, 2015The Department of Surgery recently launched a new website for the Pomerantz Lab. The site showcases the laboratory's research focused on harnessing regeneration biology to drive clinical advances in reconstructive and craniofacial medicine. Led by Jason Pomerantz, MD, Associate Professor in the Division of Plastic and Reconstructive Surgery and Surgical Director of the UCSF Craniofacial Center, the laboratory studies basic and translational aspects of tissue regeneration. Its research is [...]
- UCSF Pomerantz Lab - September 25, 2015UCSF News reports on the work of a research team, led by UCSF plastic and reconstructive surgeon Jason Pomerantz, MD, in which human muscle stem cells were successfully isolated with the potential to replicate and repair damaged muscles when grafted onto an injured site. UC San Francisco researchers have successfully isolated human muscle stem cells and shown that the cells could robustly replicate and repair damaged muscles when grafted onto an injured site. The laboratory finding paves [...]
- UCSF Pomerantz Lab - August 06, 2010A research group at Stanford University, led by Helen M. Blau, Jason H. Pomerantz (pictured left), now an Assistant Professor of Surgery in the Division of Plastic and Reconstructive Surgery at UCSF, and Kostandin V. Pajcini, has, as reported by the NY Times, "taken a possible first step toward unlocking the human ability to regenerate. By inactivating two genes that work to suppress tumors, they got mouse muscle cells to revert to a younger state, start dividing and help repair tissue."